FAP and Diet

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by Mary Chapman |

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FAP and diet

Environmental factors such as diet may help delay the onset and slow the progression of familial amyloid polyneuropathy (FAP).

Following are some dietary suggestions you may want to consider. But be sure to discuss with your primary physician before making any changes to your diet.

Increase hydration

FAP is a disorder characterized by the abnormal deposits of proteins — amyloids — around peripheral nerves and other tissues. The disease process in FAP occurs in the interstitial space, the compartment that surrounds tissues and is filled with interstitial fluid that ultimately allows movement of ions, proteins, and nutrients across the cell barrier. As such, that space is very sensitive to a fluid deficit. Make sure you consume enough water, or mineral water that is low in sodium without added carbonation.

Reduce salt intake in your diet

Elevated salt consumption may contribute to low-grade metabolic acidosis — excess acid in the body — and a thickening of the interstitial space of the heart muscle, blood vessel walls, and other tissues. This may hinder the transfer of substances between cells and blood vessels.

Studies suggest that acidosis may promote the denaturation of certain types of faulty TTR protein. Excess sodium in the bloodstream also can lead to high blood pressure, which can slow blood flow and lead to peripheral nerve damage, which already occurs in FAP.

Consume more fruits and vegetables

Consuming lots of fruits and vegetables could help offset significant digestive problems associated with FAP. The U.K. National Health Service (NHS) recommends everyone consume at least five portions of fresh fruit and vegetable daily.

Eat a heart-healthy diet

Heart involvement is a FAP characteristic. To avoid heart disease, many scientists suggest replacing saturated and trans-fatty acids with unsaturated, non-hydrogenated fats, and oils. They also suggest you increase your consumption of fish, fish oils, and plant-based foods.

Avoid gluten

Recent research suggests an association between gluten sensitivity and nerve pain. Starchy foods such as white bread, pasta, and pizza are high in gluten and you may want to consider lowering their consumption.

Vitamins and supplements

Vitamin B12 deficiency is a common cause of neuropathy. Lean poultry and fish are high in vitamin B12 and their consumption may help keep nerve cells healthy. Speak to your doctor about the best supplements for you and never take vitamins or supplements without first consulting your doctor.


Last updated: July 16, 2020


FAP News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.