News

Symptoms of Autonomic Neuropathy May Suggest Diagnosis of Primary Amyloidosis

Researchers presented the main features of primary amyloidosis, showing the need for careful diagnosis in patients that present with neuropathic symptoms, especially autonomic neuropathy, to correctly identify other conditions such as familial amyloid neuropathy (FAP). The study, titled “Autonomic Neuropathy and Albuminocytologic Dissociation in Cerebrospinal Fluid As the Presenting…

Tafamidis Delays Disease Progression in Patients with Transthyretin Amyloid Polyneuropathy, Pfizer Study Suggests

An interim analysis of the Phase 3 trial for tafamidis (Fx-1006A) as a therapy for patients with hereditary transthyretin amyloid polyneuropathy (TTR-FAP) shows the investigational treatment delays disease progression, Pfizer announced. The study, “Long-term safety and efficacy of tafamidis for the treatment of hereditary transthyretin amyloid…

Rare TTR Mutation Seen to Cause FAP in Chinese Family

Chinese researchers report the case of a family affected by familial amyloid polyneuropathy (FAP) caused by a less common mutation in the transthyretin (TTR) gene. Their findings might offer scientists new understanding of the disease processes in FAP, and have implications for genetic counseling, researchers said. The study,…

MIBG Scans Prove Valuable in Determining Familial Amyloid Polyneuropathy Patients’ Outcomes, Study Shows

An imaging technique that uses tiny amounts of radioactive chemicals can help doctors predict the outcomes of cases of familial amyloid polyneuropathy, according to a Portuguese study. The research also demonstrated that a liver transplant can stabilize FAP patients’ heart conditions. The University of Lisbon study was published in the journal…

Doctors Report Case of Late-Onset FAP With Difficult Diagnosis

Doctors reported the case of a man with late-onset familial amyloidotic polyneuropathy (FAP) with heart complications. The team’s analysis of the case prompted its members to call for early diagnosis of patients to prevent mortality due to FAP. The study, titled “Late-onset Familial Amyloidotic Polyneuropathy with Bence Jones Proteinuria…