Joana Carvalho, PhD, managing science editor —

The Ala97Ser mutation is the most common variant found on the TTR gene that has been associated with familial amyloid polyneuropathy (FAP) in Chinese-Malaysian patients, a study says. The findings of the study, “Ala97Ser mutation is common among ethnic Chinese Malaysians with transthyretin familial amyloid polyneuropathy,” were…

Changes in the immune system and in inflammation may occur before the formation and accumulation of amyloid deposits in people with familial amyloid polyneuropathy, with biomarkers of these alterations easily evident in the blood, new research finds. The study, “Inflammatory profiling of patients with familial amyloid polyneuropathy,” were…

Familial amyloid polyneuropathy (FAP) patients who carry the Val30Met mutation experience loss of sensation (numbness), especially sense of touch pressure, rather than heat pain or thermal sensibility, in both their arms and legs, a study has found. The study, “Kind and distribution of cutaneous sensation loss in hereditary…

Familial amyloid polyneuropathy (FAP) patients who do not have a Val30Met mutation exhibit prevalent cardiac and blood vessel dysfunction, but proper blood vessel constriction remains intact, even in patients with advanced nerve damage, a study suggests. The study, “Widespread Cardiac and Vasomotor Autonomic Dysfunction in Non-Val30Met Hereditary…