Symptoms of Familial Amyloid Polyneuropathy
Autonomic Neuropathy Symptoms
The autonomic nervous system is part of the nervous system that controls and regulates the internal organs without conscious recognition. Autonomic neuropathy, or damage to the autonomic nervous system, is the most severe problem in FAP because it has a significant impact on patients’ daily lives.
Cardiac involvement has been reported in about 5–23% of FAP cases. Older patients with FAP are at higher risk of developing cardiac complications, and 80% of FAP patients with cardiac involvement are men.
Peripheral Neuropathy Symptoms
One of the most common symptoms of FAP is peripheral neuropathy — a loss of nerve function in the periphery of the body, including the feet, legs, hands, and arms. Carpal tunnel syndrome is one of the most commonly reported symptoms of peripheral neuropathy in FAP patients.