How Age of Onset Affects Disease Progression in FAP

How Age of Onset Affects Disease Progression in FAP
0
(0)

Patients with familial amyloid polyneuropathy (FAP) may wonder how the age of onset of the symptoms relates to the progression of their disease. Here is some information that may answer those questions.

What causes FAP?

Mutations in the TTR gene cause FAP. These mutations cause the proteins the gene provides instructions to make to misfold and stick together, forming clumps known as amyloids. These amyloids interfere with tissue function and lead to the symptoms of the disease.

Age of onset of symptoms

For each person, the age of onset of disease symptoms may be different. The differences seem to depend on which particular mutation a patient has (researchers have identified more than 130 TTR mutations) and which organs the disease affects.

How age of onset relates to disease progression

Patients may be at a different stage of the disease at the time of diagnosis. As the disease progresses, patients move through stages.

On average, patients with FAP live about 10 years after receiving a diagnosis. However, in patients who receive a diagnosis after age 50, the disease seems to progress more slowly and they may live closer to 20 years after diagnosis. The exact cause of this is not clear.

New treatments and improvements in detection and diagnosis mean that life expectancy for patients is improving.

How can early diagnosis help?

Although there is no cure for FAP, there are treatments that may slow disease progression. Some interventions, such as a liver transplant, can be performed only in earlier stages of the disease because they are ineffective in later stages. So, early diagnosis is of paramount importance.

If you have a family history of FAP, you may want to talk to your doctor about whether you should get a genetic test for FAP, even if you do not have any symptoms.

 

Last updated: Aug. 13, 2020

***

FAP News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Emily holds a Ph.D. in Biochemistry from the University of Iowa and is currently a postdoctoral scholar at the University of Wisconsin-Madison. She graduated with a Masters in Chemistry from the Georgia Institute of Technology and holds a Bachelors in Biology and Chemistry from the University of Central Arkansas. Emily is passionate about science communication, and, in her free time, writes and illustrates children’s stories.
Total Posts: 0
Özge has a MSc. in Molecular Genetics from the University of Leicester and a PhD in Developmental Biology from Queen Mary University of London. She worked as a Post-doctoral Research Associate at the University of Leicester for six years in the field of Behavioural Neurology before moving into science communication. She worked as the Research Communication Officer at a London based charity for almost two years.
×
Emily holds a Ph.D. in Biochemistry from the University of Iowa and is currently a postdoctoral scholar at the University of Wisconsin-Madison. She graduated with a Masters in Chemistry from the Georgia Institute of Technology and holds a Bachelors in Biology and Chemistry from the University of Central Arkansas. Emily is passionate about science communication, and, in her free time, writes and illustrates children’s stories.
Latest Posts
  • FAP tissue biopsy
  • FAP age of onset
  • heart disease and FAP
  • eyes and FAP

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?

Leave a Comment

Your email address will not be published. Required fields are marked *

Pin It on Pinterest

Share This